Effects of Moderate and Vigorous Physical Exercises on Serum Liver Function Tests of Healthy Male Individuals in Anambra State
Keywords:
Physical exercise, Spectrophoto-metric method, Aspartate Ami-notransferase, Alanine Aminotrans-feraseAbstract
Objectives: The objective of this study was to determine and compare results of the effect of moderate and vigorous exercises on AST, Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Gamma Glutamyl Transferase (GGT), Total Bilirubin (TBIL) and Direct Bilirubin (DBIL) before exercise, two weeks after exercise and four weeks after exercise.
Methodology: Serum concentration/activity of AST, ALT, ALP, GGT, TBIL and DBIL of both vigorous exercise group (50 male individuals who played football for 2 hours daily for 5 days/week) and moderate exercise group (50 male individuals who played football for 30 minutes daily for 3 days/week) were determined using enzymatic spectrophotometric method. All data were expressed as Mean ± Standard Deviation (SD) and analyzed with Analysis of Variance (ANOVA) while multiple comparisons were done using Post Hoc test. Pearson’s correlation coefficient was used for correlational analysis.
Results: In the moderate exercise group, mean BMI was reduced while ALT, AST, ALP, GGT were increased, with TBIL and DBIL altered but no significance at P<0.05 all through. In the vigorous exercise group, mean serum ALT was significantly increased at P<0.05 mainly 4 weeks after exercise as compared with results before exercise. Mean serum AST was significantly increased all through at P<0.05. However, mean BMI was decreased while mean serum ALP and GGT were increased, with mean serum TBIL and DBIL altered but not significant at P<0.05.
Conclusion: Vigorous physical exercise can substantially increase fitness, but, moderate physical exercise, when performed frequently and over an extended period, produces enhanced biochemical parameters and reduced risks of cardiovascular disease.
References
1. Malatesta D, Werlen C, Bulfaro S, Chenevière X, Borrani F. Effect of high-intensity interval exercise on lipid oxidation during post-exercise recovery. Med Sci Sports Exerc 2009; 41 (2): 364 - 374.
2. Centers for Disease Control and Prevention (CDC). General Physical Activities Defined by Level of Intensity, 2011.
3. American College of Sports Medicine (ACSM). ACSM's Guidelines for Exercise Testing and Prescription, 6th ed, 2000.
4. McClatchey KD. Clinical laboratory medicine, 2002.
5. Nyblom H, Björnsson E, Simrén M, Aldenborg F, Almer S, Olsson R. The AST/ALT ratio as an indicator of cirrhosis in patients with PBC. Liver Int 2006; 26 (7): 840 - 845.
6. Pirone C, Quirke JM, Priestap HA, Lee DW. The Animal Pigment Bilirubin Discovered in Plants. Amer. Chem. So-ciety J 2009; 131 (8): 2830.
7. Jonas P, Ulf H, Paula P, Thomas B, Ulf M, Viktoria W. Muscular exercise can cause highly pathological liver func-tion tests in healthy men. Br. J. Clin. Pharmacol 2008; 65 (2): 253 - 259.
8. Swift DL, Johannsen NM, Earnest CP, Blair SN, Church TS. Effect of different doses of aerobic exercise training on total bilirubin levels. Med. Sci. Sports. Exerc 2012; 44 (4): 569 - 574.
9. Arinola GO, Adedapo KS, Akinosun OM, Odegbemi OB, Adediji OI. Plasma Biochemical Changes During Moderate and Vigorous Exercises. Intl. J. of Sports Sci. and Eng 2009; 3 (2): 73 – 76.
10. Odunaiya NA, Ayodele OA, Oguntibeju OO. Physical ac-tivity levels of senior secondary school students in Ibadan, Western Nigeria. The Wester Med J 2010; 22: 5 – 6.
11. Daniel WW. Biostatistics: A Foundation for Analysis in the Health Sciences, 7th ed, 1999.
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