Cytomegalovirus Retinitis in Chinese Patients of non-Hodgkin Lymphoma with Normal CD4 Counts

Authors

  • Lan Liu Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China
  • Yongfeng Xu Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R. China
  • Zhu Huang Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China
  • Yanhong Chen Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China

Keywords:

Cytomegalovirus retinitis, Non-Hodgkin lymphoma, human immunodeficiency virus, polymerase chain reaction, ganciclovir

Abstract

Objective: To manifested the clinic features in two cases of cytomegalovirus(CMV) retinitis in Chinese patients of non-Hodgkin lymphoma with normal CD4 counts.

Methods: Two patients with non-Hodgkin lymphoma presented with floaters and vision reduction in affected eyes. The patient underwent eye examination and blood investigation, and vitreous was extracted for CMV-DNA polymerase chain reaction (PCR). The patient was treated with intravenous and intravitreal ganciclovir.

Results: Fundoscopy showed typical yellow and white lesions in the retina of affected eyes. Blood investigation showed HIV(-), CMV- IgG (+) IgM (-),and CD4 T-cell counts more than 300 cells/ul. CMV DNA PCR(+) of vitreous sample supported the diagnosis of CMV retinitis. Retinitis regressed after the treatment of ganciclovir.

Conclusions: CMV retinitis occurred in non-HIV disease such as non-Hodgkin lymphoma with normal CD4 counts. These cases showed CMV-DNA PCR of vitreous may be a good marker for CMV retinitis and intravitreal ganciclovir may be an effective treatment.

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Published

2013-10-01

How to Cite

Lan Liu, Yongfeng Xu, Huang, Z., & Yanhong Chen. (2013). Cytomegalovirus Retinitis in Chinese Patients of non-Hodgkin Lymphoma with Normal CD4 Counts. International Journal of Medical Research, 1(04), 28–30. Retrieved from https://ijmrinternational.in/index.php/ijmr/article/view/31

Issue

Vol. 1 No. 04 (2013)

Section

Short Communication

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The authors retain the copyright of their article, with first publication rights granted to Medsci Publications.