Is Inherited Thrombphilia in Pregnancy a Risk Factor for Familial Stroke?

Authors

  • Seyed Shamseddin Hejazi Department of Neurology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
  • Cyrus Azimi Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  • Tayebeh Sabokbar Department of Neurology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
  • Abbas Shakoori Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran

Keywords:

Recurrent Pregnancy Loss (RPL), Genetics risk factors, Thrombophilia

Abstract

Context: Inherited thrombophilia is an abnormality of blood coagulation that increases the risk of thromboembolic disease. During pregnancy, the thrombogenic potential of this inherited disorder is enhanced because of the hypercoagulable state produced by normal pregnancy-associated changes in several coagulation factors.

Aims: The purpose of this research was to find the association of polymorphisms and mutations of coagulation factors.

Settings and Design: This Study is the first comprehensive study of thrombophilia genes in the Iranian population.

Methods and Material: This current research was performed in a group of 70 women referred to the Department of Medical Genetics. due to reproductive failures with history of thrombosis in pregnancy, First degree families have a history of heart attacks and strokes. The clinical data on family history of diabetes, high cholesterol, high blood pressure, a history of recurrent pregnancy loss has been observed.

Results: The most common mutation was PAI-1 with (62.9 %) heterozygote 4G/5G alleles and (14.3%) homozygote 4G/4G alleles. The second and third mutations were MTHFR-C677 T with (44.3%) heterozygote and (8.6%) homozygotes and MTHFR-1298 C with (41.4%) heterozygotes and (12.9%) homozygotes.

Conclusions: These data indicate that polymorphic variation in the prevalence of thrombophilia in women with recurrent miscarriage with our population has had a lot of different European populations. Mutations in this gene in the percentage of individuals who have a family history of stroke or heart rate have been observed.

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Published

2013-10-01

How to Cite

Seyed Shamseddin Hejazi, Azimi, C., Sabokbar, T., & Shakoori, A. (2013). Is Inherited Thrombphilia in Pregnancy a Risk Factor for Familial Stroke?. International Journal of Medical Research, 1(04), 7–11. Retrieved from https://ijmrinternational.in/index.php/ijmr/article/view/27

Issue

Vol. 1 No. 04 (2013)

Section

Original Research Articles

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The authors retain the copyright of their article, with first publication rights granted to Medsci Publications.