Heart Rate Variability a Cardiac Indicator in Diabetic Autonomic Neuropathy: A Systematic Review
Keywords:
Heart Rate, Cardiac Indicator, Diabetic Autonomic Neuropathy, Diabetes MellitusAbstract
Background: Cardiac indicator Heart Rate variability (HRV) is a significant sensitive and early predictor, which could be used for early deduction of complications among Diabetes Mellitus patients. Many studies have reported the usefulness of HRV as diagnostic method, however, there is a gap in the literature in the utilization of HRV in the clinical practice in planning, providing, and evaluating quality care for patients with diabetic autonomic neuropathy.
Purpose: The purpose of this systematic review it was to review the cardiac indicators of diabetic autonomic neuropathy.
Method: A Systematic Review of published clinical research articles from PUBMED data source was performed and the review is organized under method and result section. The research articles were selected for the review with inclusion criteria including clinical research studies, addressing concepts of HRV, diabetes mellitus, and autonomic neuropathy.
Conclusion: The review concluded that existing literature support that the HRV is a sensitive cardiac indicator, which may help to predict the cardiac morbidity and mortality among diabetes mellitus patients. HRV may be used as a significant cardiac indicator to predict diabetic autonomic neuropathy. This finding may be useful in the early diagnosis and treatment of complications among patients with diabetes mellitus.
References
1. Chessa M, Butera G, Lanza GA, Bossone E, Delogu A, De Rosa G, et al. Role of heart rate variability in the early diagnosis of diabetic autonomic neuropathy in children. Herz. 2002;27(8):785-90. Epub 2003/02/08. doi: 10.1007/s00059-002-2340-4. PubMed PMID: 12574897.
2. Bolsin SN, Raineri F, Lo SK, Cattigan C, Arblaster R, Colson M. Cardiac complications and mortality rates in diabetic patients following non-cardiac surgery in an Australian teaching hospital. Anaesthesia and intensive care. 2009;37(4):561-7. Epub 2009/08/18. PubMed PMID: 19681411.
3. Beljic T. [Frequency of vascular complications in diabetic patients with subclinical cardiac dysfunction]. Srpski arhiv za celokupno lekarstvo. 1994;122(1-2):40-2. Epub 1994/01/01. PubMed PMID: 17972803.
4. Thuesen L, Christiansen JS, Mogensen CE, Henningsen P. Cardiac hyperfunction in insulin-dependent diabetic patients developing microvascular complications. Diabetes. 1988;37(7):851-6. Epub 1988/07/01. PubMed PMID: 3384184.
5. Valensi P, Paries J, Attali JR. Cardiac autonomic neuropathy in diabetic patients: influence of diabetes duration, obesity, and microangiopathic complications--the French multicenter study. Metabolism: clinical and experimental. 2003;52(7):815-20. Epub 2003/07/19. PubMed PMID: 12870154.
6. Zarich SW, Pierce ET, Nesto RW, Mittleman MA, Bode RH, Kowalchuk G, et al. Age and history of cardiac disease as risk factors for cardiac complications after peripheral vascular surgery in diabetic patients. Mayo Clinic proceedings Mayo Clinic. 2001;76(1):34-8. Epub 2001/01/13. doi: 10.4065/76.1.34. PubMed PMID: 11155410.
7. Juul AB, Wetterslev J, Kofoed-Enevoldsen A. Long-term postoperative mortality in diabetic patients undergoing major non-cardiac surgery. European journal of anaesthesiology. 2004;21(7):523-9. Epub 2004/08/21. PubMed PMID: 15318463.
8. Astrup AS, Tarnow L, Rossing P, Hansen BV, Hilsted J, Parving HH. Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. Diabetes care. 2006;29(2):334-9. Epub 2006/01/31. PubMed PMID: 16443883.
9. Nilsson H, Bergstrom B, Lilja B, Juul-Moller S, Carlsson J, Sundkvist G. Prospective study of autonomic nerve function in type 1 and type 2 diabetic patients: 24 hour heart rate variation and plasma motilin levels disturbed in parasympathetic neuropathy. Diabetic medicine : a journal of the British Diabetic Association. 1995;12(11):1015-21. Epub 1995/11/01. PubMed PMID: 8582123.
10. Oikawa N, Umetsu M, Toyota T, Goto Y. Quantitative evaluation of diabetic autonomic neuropathy by using heart rate variations: relationship between cardiac parasympathetic or sympathetic damage and clinical conditions. The Tohoku journal of experimental medicine. 1986;148(2):125-33. Epub 1986/02/01. PubMed PMID: 3961794.
11. Braune HJ, Geisendorfer U. Measurement of heart rate variations: influencing factors, normal values and diagnostic impact on diabetic autonomic neuropathy. Diabetes research and clinical practice. 1995;29(3):179-87. Epub 1995/09/01. PubMed PMID: 8591711.
12. Yoshioka K, Tanaka K. Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1995;27(1):43-4. Epub 1995/01/01. doi: 10.1055/s-2007-979907. PubMed PMID: 7729794.
13. Yoshioka K, Terasaki J. Relationship between diabetic autonomic neuropathy and peripheral neuropathy as assessed by power spectral analysis of heart rate variations and vibratory perception thresholds. Diabetes research and clinical practice. 1994;24(1):9-14. Epub 1994/05/01. PubMed PMID: 7924888.
14. Lagi A, Cipriani M, Paggetti C, Fattorini L, Macerata A, Gensini GF. Power spectrum analysis of heart rate variations in the early detection of diabetic autonomic neuropathy. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 1994;4(5):245-8. Epub 1994/10/01. PubMed PMID: 7888743.
15. Watkins PJ, Mackay JD. Assessment of diabetic autonomic neuropathy using heart rate monitoring. Hormone and metabolic research Supplement series. 1980;9:69-72. Epub 1980/01/01. PubMed PMID: 6929780.
16. Mackay JD, Page MM, Cambridge J, Watkins PJ. Diabetic autonomic neuropathy. The diagnostic value of heart rate monitoring. Diabetologia. 1980;18(6):471-8. Epub 1980/06/01. PubMed PMID: 7418957.
17. Neil HA, Thompson AV, John S, McCarthy ST, Mann JI. Diabetic autonomic neuropathy: the prevalence of impaired heart rate variability in a geographically defined population. Diabetic medicine : a journal of the British Diabetic Association. 1989;6(1):20-4. Epub 1989/01/01. PubMed PMID: 2522369.
18. Murata K, Sumida Y, Murashima S, Matsumura K, Takeda H, Nakagawa T, et al. A novel method for the assessment of autonomic neuropathy in type 2 diabetic patients: a comparative evaluation of 123I-MIBG myocardial scintigraphy and power spectral analysis of heart rate variability. Diabetic medicine : a journal of the British Diabetic Association. 1996;13(3):266-72. Epub 1996/03/01. doi: 10.1002/(SICI)1096-9136(199603)13:3<266::AID-DIA72>3.0.CO;2-4. PubMed PMID: 8689849.
19. Mitchell EA, Wealthall SR, Elliott RB. Diabetic autonomic neuropathy in children: immediate heart-rate response to standing. Australian paediatric journal. 1983;19(3):175-7. Epub 1983/09/01. PubMed PMID: 6360117.
20. Matsuto T, Inano K, Miida T, Okada M. [Assessment of diabetic cardiovascular autonomic neuropathy by heart rate variability and pulse wave velocity]. Rinsho byori The Japanese journal of clinical pathology. 1998;46(10):1037-42. Epub 1998/11/17. PubMed PMID: 9816916.
21. Ermis N, Gullu H, Caliskan M, Unsal A, Kulaksizoglu M, Muderrisoglu H. Gabapentin therapy improves heart rate variability in diabetic patients with peripheral neuropathy. Journal of diabetes and its complications. 2010;24(4):229-33. Epub 2009/02/07. doi: 10.1016/j.jdiacomp.2008.12.001. PubMed PMID: 19195912.
22. Colberg SR, Swain DP, Vinik AI. Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. Diabetes care. 2003;26(4):986-90. Epub 2003/03/29. PubMed PMID: 12663561.
23. Khoharo HK, Halepoto AW. QTc-interval, heart rate variability and postural hypotension as an indicator of cardiac autonomic neuropathy in type 2 diabetic patients. JPMA The Journal of the Pakistan Medical Association. 2012;62(4):328-31. Epub 2012/07/05. PubMed PMID: 22755273.
24. Burger AJ, Weinrauch LA, D'Elia JA, Aronson D. Effect of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy. The American journal of cardiology. 1999;84(6):687-91. Epub 1999/09/25. PubMed PMID: 10498140.
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